https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Noxa upregulation by oncogenic activation of MEK/ERK through CREB promotes autophagy in human melanoma cells https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19023 V600E or MEK downregulated Noxa, whereas activation of MEK/ERK caused its upregulation. In addition, introduction of BRAFV600E increased Noxa expression in melanocytes. Upregulation of Noxa was due to a transcriptional increase mediated by cAMP responsive element binding protein, activation of which was also increased by MEK/ERK signaling in melanoma cells. Significantly, Noxa appeared necessary for constitutive activation of autophagy, albeit at low levels, by MEK/ERK in melanoma cells. Furthermore, it was required for autophagy activation that delayed apoptosis in melanoma cells undergoing nutrient deprivation. These results reveal that oncogenic activation of MEK/ERK drives Noxa expression to promote autophagy, and suggest that Noxa has an indirect anti-apoptosis role in melanoma cells under nutrient starvation conditions.]]> Wed 11 Apr 2018 16:41:25 AEST ]]> MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13811 Wed 11 Apr 2018 15:41:21 AEST ]]> TRIM16 inhibits proliferation and migration through regulation of interferon beta 1 in melanoma cells https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18837 Wed 11 Apr 2018 15:08:53 AEST ]]> PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14353 Wed 11 Apr 2018 11:50:58 AEST ]]> INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22865 Wed 11 Apr 2018 09:31:09 AEST ]]> Skp2-mediated stabilization of MTH1 promotes survival of melanoma cells upon oxidative stress https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32181 Wed 09 Mar 2022 15:58:36 AEDT ]]> Confocal microscopy, dermoscopy, and histopathology features of atypical intraepidermal melanocytic proliferations associated with evolution to melanoma in situ https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44783 Tue 30 Apr 2024 09:05:42 AEST ]]> The regenerating naevus https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29180 Thu 24 Mar 2022 11:30:18 AEDT ]]> Expression of glucose-regulated stress protein GRP78 is related to progression of melanoma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6919 1.0 mm) primary melanoma. It was 18 and 17.3 in subcutaneous and lymph node metastases, respectively (P < 0.0001). GRP78 expression was positively correlated with increasing tumour thickness (P = 0.001) and with increasing dermal tumour mitotic index (P = 0.0004). Disease-free survival (χ² = 8.0703, P = 0.0045) and overall survival (χ² = 6.2633, P = 0.0123) in melanoma patients with IRS >25 were significantly lower than in melanoma patients with IRS <25. Conclusions: GRP78 expression appears to correlate with known correlates of melanoma progression and survival and requires further evaluation as a prognostic biomarker in melanoma.]]> Sat 24 Mar 2018 08:34:50 AEDT ]]> Progression in melanoma is associated with decreased expression of death receptors for tumor necrosis factor–related apoptosis-inducing ligand https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1240 Sat 24 Mar 2018 08:28:31 AEDT ]]> The emerging important role of microRNAs in the pathogenesis, diagnosis and treatment of human cancers https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15221 Sat 24 Mar 2018 08:26:08 AEDT ]]> Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10937 1.0mm) (95%) and in metastatic melanoma in the skin (100%) and lymph node (81%). The immunoreactive score was highly related to progression of melanoma (P<0.0001). LDH5 expression was positively associated with increasing tumor thickness (P=0.02) and dermal tumor mitotic rate (P=0.02). LDH-5 above the median immunoreactive score was associated with reduced disease-free survival and overall survival (P<0.02). LDH-5 expression was negatively associated with Bcl-2 expression. In contrast, LDH-5 expression was strongly associated with Bcl-XL and Mcl-1 expression and also positively associated with GRP78 expression (P<0.0001). The low Bcl-2 expression in melanomas with high LDH-5 expression provides an explanation for the poor response of patients with high serum LDH levels to treatment with the Bcl-2 antisense drug ‘Genasense’. The strong correlation of LDH-5 expression with Mcl-1 expression suggests that treatment strategies inhibiting the activity of Mcl-1 in melanoma patients should be investigated.]]> Sat 24 Mar 2018 08:13:21 AEDT ]]> RIP1 kinase is an oncogenic driver in melanoma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26954 Sat 24 Mar 2018 07:27:01 AEDT ]]> Expression of NGF/proNGF and Their Receptors TrkA, p75<sup>NTR</sup> and Sortilin in Melanoma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51398 Mon 04 Sep 2023 14:57:50 AEST ]]> BRAF mutation testing for patients diagnosed with stage III or stage IV melanoma: practical guidance for the Australian setting https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47367 Fri 13 Jan 2023 14:57:43 AEDT ]]>